Facilities

Peakdale Molecular endeavours to acquire the widest range of the latest state-of-the-art equipment to furher accelerate it customers chemistry initiatives.

 
CHEMISTRY FACILITIES (Kilo Scale)

  • 9 Research laboratories with scales from mg to kg
  • 2 Large contract research laboratories
  • Scale-up laboratory reactors - 30Land 50L jacketed vessels
  • Low temperature capabilities - up to 30 litres at -78°C
  • Pressure vessels up to 7.8 litres
  • Microwave reactors up to 1ml to 1l
  • 5L & 10L test rigs for hazard evaluation
  • 2 x 10L, 4 x 6L jacketed vessels
  • Carius apparatus for reaction screening to assist with scale-up
     

CHEMISTRY FACILITIES (Parallel Synthesis)

  • Growing reaction database
  • Parallel reaction blocks (Stem, Metz, Greenhouse, Carousel)
  • Zinsser Lissy liquid handling
  • Parallel purification (filtration, Flashmaster)
  • Genevac HT12
  • Waters Mass Directed Preparative HPLC


ANALYTICAL FACILITIES

  • 5 Analytical HPLC (2 with MS), chiral chromatography
  • UPLC-MS
  • GC (FID)
  • Karl Fischer
  • 300MHz and 400MHz (Jeol) - NMR
  • Open access 1D spectra for 1H, 13C, 19F, 11B and 31P - NMR
  • Open access 2D spectra such as COSY, HETCOR, NOESY - NMR
  • On request specialist experiments (1D nOe difference, other nuclei) - NMR
  • Variable temperature - NMR
  • Structural & purity confirmation/elucidation - NMR


PURIFICATION FACILITIES

  • 4 prep. HPLC with PDA and/or ELS
  • Mass directed prep. HPLC


ADME FACILITIES

  • Thermo Fisher Triple Quad Mass spectrometer
  • Serum /Plasma protein Binding
  • Plasma stability (human + species on demand)
  • Microsomal stability (human + species on demand)
  • CYP450 inhibition
  • Cytotoxicity
  • CACO2 permeability (bidirectional)
  • In silico & measured physical chemistry properties


COMPUTATIONAL CHEMISTRY FACILITIES

  • Virtual screening
  • Pharmacophore modelling and QSAR methods
  • Ligand docking
  • Protein homology modelling
  • ADMET
  • Array design
  • Licensed software includes: Discovery Studio (Accelrys); Cresset's Molecular Field Software; Dragon


LIBRARY FACILITIES

  • Extensive library of hard copy journals covering all important synthetic organic and medicinal chemistry literature
  • Online access to Science Direct
  • Literature searching capabilities include Reaxys and SciFinder