Medicinal Chemistry Services
Peakdale has successfully undertaken exclusive and confidential contract research projects for a number of blue-chip pharmaceutical companies and an increasing number of biotechnology companies.
The Company offers a range of medicinal chemistry services utilising the development of its innovative synthetic chemistry and computer-aided drug design expertise to support its customers’needs. These are based on the following key principles:
- Flexible and responsive dedicated teams of chemists
- Complete confidentiality with customers’retaining all intellectual property
- Delivery of the required materials on time, in full
- Clear and constant communication
- Quality control throughout
There are numerous and varied types of projects that can benefit from Peakdale’s adaptable approach including hit to lead and lead optimisation projects, patent exemplification work, and the design and synthesis of exclusive chemogenetic arrays.
Hit-to-lead and lead optimisation projects can include:
- Optimising selectivity, ligand-receptor binding and enzyme inhibition
- Enhancing ADMET and pharmacokinetic properties
- Conducting QSAR analyses, structure-based drug design
- Backup chemotypes
- Fast follower candidates
The synthesis of exclusive chemogenetic arrays give customers compounds with:
- Unique, privileged scaffolds
- Robust ADMET properties
- Non-hERG solubilising groups
The Company’s Medicinal Chemistry Services are undertaken through focused multi-disciplinary teams of PhD scientists, led by an experienced Technical Manager. Peakdale’s teams liaise directly with customers to ensure a specialised, customer-focused relationship which complements their drug discovery programmes.
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