Nucleoside and Nucleotide Services

Peakdale Molecular has particular expertise in the specialist chemistry, purification and analytical techniques required to synthesise these challenging compounds.

 

"I have always felt that the chemists at Peakdale do fantastic work, communicate extremely

well and are a pleasure to work with"

(Sr. Principal Scientist, Top 5 pharma company)

 

CAPABILITIES

Led by highly experienced project managers, veterans of a multi-year FTE programme in this area, our teams can undertake all aspects of nucleoside and nucleotide projects. This combination of experience and expertise means rapid acclimatisation to the client's project, creative strategies for compound design and world class synthetic execution. All this shortens the client's discovery time whilst providing timely solutions.Nucleoside Chemistry Services

We have considerable experience in the relevant synthesis of:

  • Novel sugars
  • Novel purine and pyrimidine derived bases.
  • Innovative use of couplings such as Vorbruggen, PTC and BF3OEt2 etc.
  • Incorporation of phosphonate linkages and further synthetic manipulation of nucleotides

 

Compound purification and characterisation are achieved by:

  • Validated HPLC/Ion exchange systems and methods specifically for nucleosides/ nucleotides
  • ELS & MS prep.HPLC detectors for purification of UV-inactive sugars
  • Christ Alpha 2-4 LSC Freeze dryer for isolation of purified material
  • 300 & 400MHz NMR for stereochemistry determination experiments

 

BENEFITS

Projects are delivered with the 'lab down the corridor' approach we take to all projects. Our expertise in problem solving means we aim to work with you, not just for you, providing solutions to problems and when necessary offering alternative strategies.

Our problem-solving approach is coupled with our total customer focus: pro-active communication that is tailored to your needs, with comprehensive updates, reports and data as required. We are a service company and so all intellectual property created in the project remains wholly in the client's ownership.

In short, we offer:

  • Creative expertise applied to your project giving....
  • Rapid & viable Solutions to research needs, yielding....
  • Value-for-money and peace of mind

 

PEAKDALE NUCLEOSIDE CHEMISTRY LITERATURE

A Flexible, Efficient Synthesis of (±)-Carbocyclic Phosphonic Acid Nucleoside Derivatives

P. Wainwright et al. SYNLETT 2005, No. 5, pp 0765-0768 (DOI: 10.1055/s-2005-863745)

Synthesis of Enantiomerically Pure 4-Substituted Riboses

A. Maddaford et al. SYNLETT 2007, No. 20, pp 3149-3154 (DOI: 10.1055/s-2007-1000822)

Stereoselective Synthesis of rac-4'-ethynyl-2'-deoxy- and 4'-Ethynyl-2',3'-dideoxy-2',3'-didehydronucleoside Analogues

A. Maddaford et al. SYNTHESIS 2007, No. 9, pp 1378-1384 (DOI: 10.1055/s-2007-966009)

Synthesis of novel 2-cyano-7-deaza-8-azapurine and 2-cyano-8-azapurine derived nucleosides

P Wainwright et al. Synlett 2011, no. 13, pp 1900-1904 (DOI: 10.1055/s-0030-1260943)

Practical Synthetic Routes to Carbon-Substituted Nucleosides

D.C. Pryde et al. Tet. Lett. 2011, Vol. 52, Iss. 48, pp 6415-6419 (DOI: 10.1016/j.tetlet.2011.09.074)